Competency 208.5.4: Enzymology and Catalytic Mechanism – The graduate constructs models of enzymes, demonstrates how enzymes act as a catalyst in a reaction and factors that influence this reaction, and solves enzyme and catalysis problems.

Competency 208.5.5: Carbohydrate Metabolism, Adenosine Triphosphate (ATP) – The graduate constructs models of carbohydrates and demonstrates metabolism of carbohydrates; demonstrates how adenosine triphosphate (ATP) is essential to energy transfer in the cell and how irregularities in ATP synthesis in the cell can cause cytopathologies.


Task 4: Metabolism


More and more researchers are discovering that many diseases are caused by biochemical deficiencies or defects. That is, instead of indicating that a disease is caused by a nutritional deficiency, researchers recognize that an underlying cause may be a single molecular structure within a cell that fails to turn a cellular process on or off. This is particularly true regarding metabolism. For this task, you will consider the biochemical implications in a metabolic disorder involving a normal component of food—fructose.

You should compile your work for this task in a single document (e.g., Microsoft Word, Google Document) that includes diagrams, text explanations, and references. If a requirement asks for an explanation, you should provide a written response in a narrative style (i.e., complete sentences rather than bullet points).

Note: Multimedia presentations (e.g., PowerPoint, Keynote) will not be accepted due to potential originality concerns.

Note: Please save submission documents as *.doc, *.docx, *.rtf, or *.pdf files. If you are using Google Documents, you must save the file in *.pdf format and upload the *.pdf file.


Demonstrate your understanding of the biochemical basis of hereditary fructose intolerance (HFI) by doing the following:
Describe two important features that make all enzymes catalysts.

Explain the reactions catalyzed by enzymes in the first two steps of fructose metabolism in the liver, including each of the following:
the substrates acted on
the enzyme catalysts
the products generated
Discuss how a deficiency in aldolase B is responsible for HFI by doing the following:
Explain how the amount of the substrate of aldolase B is impacted by the deficiency.
Explain the role of the substrate in producing one condition of HFI (e.g., hypoglycemia, liver failure).

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